Doctors warn that you are really rolling the dice with this drug. There have been no long-term studies of Provigil and its effects on healthy brains have never been studied. Doctors also warn that possible side effects include sleep deprivation and potentially lethal rashes and worse.
Provigil is not a substitute for sleep. Sleep deprivation can cause and worsen heart disease, diabetes and high blood pressure, said Dr. Joanne Getsy, chief of the Sleep Medicine Section at the Drexel University College of Medicine in Philadelphia.
And there have been no studies proving that performance actually improves with Provigil. Sleep deprivation can actually worsen performance, said Getsy.
Its very tempting, but I think long-term its a bad idea, said Dr. Martha Farah, a cognitive neuroscientist at the University of Pennsylvania. We actually know very little about the long term effects.

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